Smarter Experimental Design, Tailored to Your Research

Turning complex biological questions into reproducible, impactful studies.

At ImmSilico, we specialise in designing biologically insightful, statistically powered, and cost-effective studies that address the real-world complexities of tissue immunity research.

Whether you’re planning single-cell, spatial, or multi-omic experiments—or combining them—we tailor every design to the specific biological question and resource constraints.

 From early hypothesis refinement to final integration, we guide your team with expert input on sample strategy, technology selection, and study parameters. Our goal is to help you avoid common design pitfalls, reduce unnecessary costs, and maximise research impact.

Bridging preclinical and clinical insights through robust experimental design.

Specific Services We Offer

Experimental Design

Minimise bias and maximise impact with tailored study design.

We support you in developing an optimised experimental design that aligns with your scientific goals and budgetary constraints. Our guidance includes:

  • Minimising technical variation and enabling regression of batch effects during data analysis

  • Enhancing signal-to-noise ratio for clearer biological insights

  • Ensuring reproducibility and statistical robustness through proper replication and control strategies

  • Advising on appropriate control sets, sample sizes, number of replicates, and target cell counts to achieve statistical power

  • Defining essential metadata and collection protocols

  • Ensuring your design remains feasible within your proposed project scope and budget

Data Integration Strategy

Seamlessly align data across modalities for deeper insights

We help you plan your experiments to support seamless data integration across multiple modalities. This includes:

  • Designing for compatibility across single-cell RNA-seq, spatial transcriptomics, proteomics, and imaging platforms

  • Structuring experiments to allow alignment of cross-modality datasets

  • Advising on suitable analytical tools and expertise needed for efficient biological signal extraction

Public Data Utilisation & Atlas Mapping

Leverage global resources to enrich your discoveries.

We support the strategic use of public datasets to enrich and contextualise your data. Services include:

  • Identifying relevant reference datasets for annotation, benchmarking, and alignment

  • Supporting label transfer, signature enrichment, and cross-study harmonisation

  • Mapping to reference atlases (e.g., Healthy Colon, IBD, CPI-Colitis) for comparative analysis

Grant Application Support

Strengthen your proposals with expert, evidence-based input.

We provide expert input to strengthen your funding proposals:

  • Evaluating the appropriateness and feasibility of your proposed experimental design

  • Advising on methodology, platform selection, and study rationale

Use case and Track Record

• Designed a multi‑platform IBD study integrating human and murine scRNA‑seq, spatial data, and CyTOF to uncover crypt‑niche remodelling and inflammatory signatures.

• Developed a comparative study design for checkpoint inhibitor‑induced colitis vs. ulcerative colitis using spatial and TCR tracking.

• Led statistical design and sampling for a tumour study on antigen‑specific CD4/CD8 T cells using tetramers and single‑cell sequencing.

Start With a Smarter Foundation

Partner with ImmSilico to design reproducible, powerful, and integrative studies—right from the start.

Contact Us: contact@immsilico.com