Impact That Matters
From idea to elegant experimental design, through feasibility, implementation, data generation, and knowledge extraction, we transform complex immunological questions into actionable insights — driving new hypotheses, medical translation, and lasting impact.
The foundation of ImmSilico rests on decades of pioneering research by our team. Long before ImmSilico was established, our experts led landmark studies that reshaped the field of immunology and advanced data‑driven discovery. These proven track records are the backbone of our mission today — empowering us to deliver rigorous, high‑impact consultancy for the future of immune health.
Proven Impact
Checkpoint Inhibitor Tracking in T Cells
As a major step forward in understanding immune-related adverse events in cancer patients receiving checkpoint blockade therapy, we used advanced imaging and molecular profiling to track T cells bound by checkpoint inhibitors within intestinal tissue of patients experiencing checkpoint-induced colitis.
Cancer Cell 2024
Single Cell Atlas of Colonic CD8+ T Cells in Ulcerative Colitis
Through pioneering single-cell RNA sequencing in a collaborative effort, ImmSilico helped construct a comprehensive atlas of colonic CD8+ T cells in both healthy individuals and those with ulcerative colitis. This work revealed the heterogeneity and functional states of these cells, offering deeper insight into UC mechanisms and paving the way for targeted therapies.
Nature Medicine 2020
Spatiotemporal Analysis of Human Intestinal Development
In collaboration with world-leading researchers, the ImmSilico team leveraged single-cell and spatial transcriptomics to map intestinal development. This study delivered an unprecedented view of the crypt–villus axis and uncovered new insights into neural, vascular, and immune maturation within the gut.
Cell 2020