Empowering Discovery With The Right Experimental Technologies
Strategic guidance to select, implement, and optimise cutting‑edge experimental platforms in tissue and blood immunity.
At ImmSilico, we help researchers and organizations navigate the rapidly evolving landscape of experimental technologies to design successful studies in tissue and blood immunity.
Whether you're exploring single-cell transcriptomics, spatial platforms, immune repertoire sequencing, novel antigen-specific experimental techniques, or emerging multi-modal approaches, we provide expert, unbiased guidance on selecting and implementing the most suitable technologies for your research goals.
Our strategic consultancy evaluates technical capabilities, feasibility, scalability, usability, and costs to ensure chosen technologies align with your scientific objectives, sample constraints, and budget. We support research teams and industry partners in making informed, evidence-based decisions that minimize technical and logistical risks while maximizing scientific outcomes.
Use of powerful imaging/spatial technologies to capture localised cellular landscape and molecular signatures of tissue of interest.
Specific Services We offer
Technology Selection and Appropriateness
Helping you identify and implement the right platform for your research goals.
Strategic guidance on evaluating and selecting advanced sequencing and imaging technologies including scRNA-seq, TCR/BCR-seq, and spatial transcriptomics platforms (e.g., 10x Genomics, CosMx, Visium, NanoString).
Assess platform compatibility with specific scientific aims—such as tracking antigen-specific T cells or identifying niche-resident populations in tissue- and disease-specific contexts.
Advise on feasibility, applicability, and tailored use of emerging technologies in relation to sample constraints, budget, and intended resolution.
Identify and mitigate technical limitations (e.g., cell recovery rates, library preparation issues, detection thresholds).
Multimodal Strategy Design
Building cohesive, interpretabel pipelines across cutting-edge modalities.
Recommend and evaluate multimodal combinations (e.g., scRNA-seq + tetramer staining, CITE-seq + VDJ, CyTOF + spatial imaging) tailored to complex immunological questions.
Support integrative planning across modalities for cohesive, interpretable study outputs.
Custom Panel & Protocol Design
Tailored reagent and workflow design to fit complex immunological studies.
Assist in designing antibody panels, tetramers, spatial probes, and multimodal reagents.
Guide the creation of metadata schemas and replicate planning for downstream analysis and reproducibility.
Optimise workflows for rare or niche cell types (e.g., stromal enrichment in mesenchymal or barrier tissue studies).
Pilot Study Design & Risk Assessment
Design pilot or proof-of-concept studies to de-risk large-scale experiments.
Provide strategic input for grant applications, including platform justification, anticipated outcomes, and risk mitigation strategies.
Vendor & Partnership Strategy
Recommend experienced vendors and contract research organisations (CROs) suited to your project’s needs.
Support quote reviews, assess timeline feasibility, and advise on assay implementation logistics.
Decoding the architecture of immune recognition—paving the way for targeted therapies and mechanistic breakthroughs.
Use Case and Track Record
• Designed and implemented a single-cell + TCR-seq workflow to track antigen-specific CD4/CD8 T cells in a mouse tumour model.
• Supported research teams in applying CosMx spatial transcriptomics to identify CPI-bound T cells in CPI-colitis tissue
• Provided strategic guidance on enriching crypt niche mesenchymal cells from inflamed human colon tissue?
Questions About a Project?
Ready to take the next step? Let’s discuss your experimental goals and identify the most powerful, cost‑effective technologies for your needs.
Contact Us: contact@immsilico.com