Empowering Discovery Through The Right Experimental Strategies

At ImmSilico, we help researchers and organizations navigate the rapidly evolving landscape of experimental technologies to design successful studies in tissue and blood immunity. Whether you're exploring single-cell transcriptomics, spatial platforms, immune repertoire  sequencing, novel antigen-specific experimental techniques, or emerging multi-modal approaches, we provide expert, unbiased guidance on selecting and implementing the most suitable technologies for your research goals.

Our strategic consultancy evaluates technical capabilities, feasibility, scalability, usability, and costs to ensure chosen technologies align with your scientific objectives, sample constraints, and budget. We support research teams and industry partners in making informed, evidence-based decisions that minimize technical and logistical risks while maximizing scientific outcomes and delivering robust, high-quality data.

From initial technology assessment through implementation optimisation, we accelerate discoveries in tissue immunity by ensuring you have the right experimental strategy to answer your most important biological questions.

Use of powerful spatial technologies to capture localised cellular landscape and molecular signatures of tissue of interest.

Specific Services We offer

Technology Selection and Appropriateness

  • Strategic guidance on evaluating and selecting advanced sequencing and imaging technologies including scRNA-seq, TCR/BCR-seq, and spatial transcriptomics platforms (e.g., 10x Genomics, CosMx, Visium, NanoString).

  • Assess platform compatibility with specific scientific aims—such as tracking antigen-specific T cells or identifying niche-resident populations in tissue- and disease-specific contexts.

  • Advise on feasibility, applicability, and tailored use of emerging technologies in relation to sample constraints, budget, and intended resolution.

  • Identify and mitigate technical limitations (e.g., cell recovery rates, library preparation issues, detection thresholds).

Multimodal Strategy Design

  • Recommend and evaluate multimodal combinations (e.g., scRNA-seq + tetramer staining, CITE-seq + VDJ, CyTOF + spatial imaging) tailored to complex immunological questions.

  • Support integrative planning across modalities for cohesive, interpretable study outputs.

Custom Panel & Protocol Design

  • Assist in designing antibody panels, tetramers, spatial probes, and multimodal reagents.

  • Guide the creation of metadata schemas and replicate planning for downstream analysis and reproducibility.

  • Optimise workflows for rare or niche cell types (e.g., stromal enrichment in mesenchymal or barrier tissue studies).

Pilot Study Design & Risk Assessment

  • Design pilot or proof-of-concept studies to de-risk large-scale experiments.

  • Provide strategic input for grant applications, including platform justification, anticipated outcomes, and risk mitigation strategies.

Vendor & Partnership Strategy

  • Recommend experienced vendors and contract research organisations (CROs) suited to your project’s needs.

  • Support quote reviews, assess timeline feasibility, and advise on assay implementation logistics.

Decoding the architecture of immune recognition—paving the way for targeted therapies and mechanistic breakthroughs.

Decoding the architecture of immune recognition—paving the way for targeted therapies and mechanistic breakthroughs.

Use Case and Track Record

• Designed a single-cell + TCR-seq workflow to track antigen-specific CD4/CD8 T cells in a mouse tumour model using GP33 tetramers

• Supported the use of CosMx spatial transcriptomics to identify CPI-bound T cells in CPI-colitis tissue

• How to enrich crypt niche mesenchymal cells from inflamed human colon tissue?

Questions About a Project?

Let’s discuss your experimental goals and help you choose the most powerful, cost-effective technologies for your needs.

Contact Us: contact@immsilico.com